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Article: A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Liang C; Kelsey KT; McClean MD; Christensen BC; Marsit CJ; Karagas MR; Waterboer T; Pawlita M; Nelson HH
PLoS ONE, 2015


10.1371/journal.pone.0123716.t002 Association between <italic>TMC8</italic> genotype and HPV L1 seropositivity-all subjects.
TMC8 genotypea
HPV type AA AT TT ORAT vs AA (95% CI)b ORTT vs AA (95% CI)b
High risk
HPV16 25/176 45/350 14/165 0.91 (0.54-1.55) 0.58 (0.29-1.17)
HPV18 26/175 35/360 12/167 0.65 (0.38-1.11) 0.48 (0.24-0.99)
Other types
HPV11 13/188 25/370 14/165 0.98 (0.49-1.95) 1.23 (0.56-2.69)
HPV31 22/179 27/368 10/169 0.60 (0.33-1.09) 0.48 (0.22-1.04)
HPV33 8/193 11/384 5/174 0.70 (0.28-1.76) 0.69 (0.22-2.15)
HPV35 14/187 24/371 9/170 0.87 (0.44-1.73) 0.70 (0.30-1.66)
HPV45 10/191 16/379 4/175 0.82 (0.36-1.84) 0.43 (0.13-1.41)
HPV52 12/189 6/389 4/175 0.25 (0.09-0.67) 0.36 (0.11-1.13)
HPV58 10/191 10/385 6/173 0.51 (0.21-1.24) 0.66 (0.23-1.85)

a number of individuals L1 positive/L1 negative.

b All OR’s adjusted for sex and age.


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